Prevalence of Fibromyalgia Syndrome in Patients with Haemophilia A


ABSTRACT:BACKGROUND:Fibromyalgia syndrome is a common rheumatological syndrome with multiple systemic manifestations which could occur alone or associated with many diseases.OBJECTIVE:To detect the possible relation between fibromyalgia and haemophilia-A patients.PATIENTS AND METHODS:One hundred patients with haemophilia-a were studied and compared with another hundred, healthy individuals matched for age and sex, serving as control group. Full history was taken and complete clinical examination was done for all individuals in both groups.The american college of rheumatology 1990 criteria for fibromyalgia were applied for both groups. They were questioned about presence of chronic widespread pain, sleep disturbance, headache fatigue and parasthesia . Detection of at least 11 of 18 tender points by digital palpation of specific soft tissue sites were needed for diagnosis of fibromyalgia.RESULTS:There was a significant increase in the frequency of fibromyalgia among individuals with haemophilia-a (25%) compared to healthy control group (3%) (p=0.000004, odd ratio=0.093, 95% confidence interval 0.027-0.319).CONCLUSION:Fibromyalgia occurs with high frequency in hemophilia A patients