Experimental Study Using Cinnamon Oil for Prevention of Diabetic Nephropathy in Rats

Abstract

ABSTRACT:BACKGROUND:Diabetes mellitus is the leading cause of chronic renal failure. However, in the early phase of the disease before complications have set in, the glomerular filtration rate is elevated and kidney size increased. The clinical importance of these early aberrations derives from the hyperfilteration (the heightened glomerular capillary) that drives damages the glomerulus, and the enlargement of the kidney (the glomerulus).OBJECTIVE:The aim of the present investigations is to examine histologically the effect of cinnamon oil on the kidney tissues of alloxan – induced diabetes rats.MATERIALS AND METHODS:Fifty male rats were used and divided into four groups: Group I =12 animal controls, Group II =12 treated with alloxan, Group III = 12 treated with alloxan + cinnamon oil, Group IV = 12 treated with cinnamon oil only.RESULTS:Renal tissues (Bowman's capsule, proximal and distal convoluted tubules) of diabetes group: revealed obvious mesangial expansion and basement membrane thickening. While the diabetic treated animals with cinnamon oil ameliorated the increase in the mesangial area in diabetic rats.CONCLUSION:Cinnamon oil can be recommended as an support for the prevention of alloxan – induced diabetic complications.