COMPARATIVE EFFECTS OF LOVASTATIN AND SIMVASTATIN ON LIVER FUNCTION TESTS IN HYPERLIPIDAEMIC PATIENTS

Abstract

ABSTRACTObjective: to evaluate the effect of lovastatin and simvastatin on liver function tests in a number of hyperlipidaemicpatients.Design: case control study.Setting: the study was conducted in Al-Salam Hospital in Mosul during the period from July 2003 to July 2004.Participants: forty-two patients taking lovastatin and fifty-three patients taking simvastatin. Another fifty,apparently healthy subjects, were also involved as a control group.Intervention: ALT, AST and ALP activities and bilirubin concentrations of patients on lovastatin, simvastatin andcontrol group were compared.Main outcome measures: measurement of serum of ALT, AST and ALP activities and serum bilirubin concentrationin lovastatin, simvastatin and control groups.Results: results of the study revealed a minor elevation of ALT, AST and ALP activities and bilirubin concentrationsabove the upper normal limit values in a number of participants taking lovastatin or simvastatin therapy. Asignificant elevation of ALT, AST and bilirubin in the lovastatin group compared with the control group and asignificant elevation of ALT and bilirubin in the simvastatin group when also compared with the control group werefound. Stratification of the patients according to age, duration of treatment and dose, revealed a good correlationbetween some of the hepatic parameters and the age, duration of treatment and dose, though some of these elevationswere not statistically significant.Conclusion: therapy with lovastatin or simvastatin is associated with a mild effect on the liver and the effect is relatedto the variables of age, duration of therapy and dose. Periodic monitoring of biochemical hepatic parameters duringtherapy with lovastatin and simvastatin may be of value to observe any serious elevation of these parameters.