HUMAN RECOMBINANT ERYTHROPOIETIN IN THE TREATMENT OF ANEMIA OF PATIENTS WITH CHRONIC RENAL FAILURE

Abstract

ABSTRACTObjective: To compare the effect of small doses of recombinant erythropoietin on anemia of patients with chronickidney disease who need dialysis and those are not on dialysis.Design: Case-comparative study.Setting: Nephrology Department in Al-Salaam Teaching Hospital, Mosul.Methods: Eighty patients having chronic kidney disease (40 patients needed dialysis and 40 patients needed nodialysis) participated in the study. Epoetin alfa given s.c. in a dose of 4000 IU, 2 times weekly. Hemoglobin wasmeasured before drug administration and every 2 weeks and at the end of the trial period (3 months).Result: A significant increase of hemoglobin level had been obtained after treatment with erythropoietin in bothgroups. Comparison between hemoglobin elevation of both groups ( 3.0 g/l for patients without dialysis and 2.9 g/l forpatients with dialysis) revealed a non significant difference (P>0.5).Conclusion: the present study demonstrated that the administration of epoetin alfa, s.c. in a dose of 4000 IU twiceweekly is effective in the elevation of hemoglobin levels in patients with chronic kidney disease. The effect iscomparable in patients who need dialysis and in patients who need no dialysis, also the effect is similar in both sexes.