Hypolipoproteinemia as Biological Marker in Acute Leukemia

Abstract

ABSTRACT:BACKGROUND:Acute leukemia is a clonal hematopoietic malignant disease that arises from malignant transformationof an early hematopoietic stem cells .Seeking for biochemical markers that are associated with acuteleukemia may help us for better understanding of the leukemic process &improve our lines ofmanagement.Hypolipoproteinemia is one of these markers&it is the target of this study.OBJECTIVE:To study the association between the hypolipoproteinemia &acute leukemia &the ability of usinghypolipoproteinemia as a biological marker that is helpful in follow up of acute leukemia.PATIENT&METHODS:A total of fifty patients with acute leukemia diagnosed by blood film&bone marrow examination werecompared with control group of twenty healthy persons regarding fasting lipid profile(TC totalcholesterol,LDL low density lipoprotein,HDL high density lipoprotein,TG triglyceride).RESULTS:In this study there is close association between hypolipoproteinemia&acute leukemia. The mean valuesof lipoproteins were significantly lower in patient with acute leukemia compared to control group(Pvalue is 0.0001 for total cholesterol&0.045 for triglyceride).CONCLUSION:These data suggest that hypolipoproteinemia could be useful as a marker for follow up of acuteleukemia.