Effects of estrogen replacement therapy on symptoms and clinical parameters in post menopausal women


Objective: To evaluate the effect of oral estrogen replacement therapy (ERT) in healthypostmenopausal women on lipid profile, body mass index (BMI), blood pressure, andblood glucose; and on postmenopausal symptoms.Subjects and Methods: This prospective cohort research was carried out over a periodof eight months, from Jun 2007 to February of 2008. Fifty six postmenopausal women(mean SD age of 53.3±3 years; mean menopausal period, 5 years); previously diagnosedby gynecologist were involved in this study. Thirty six postmenopausal women weretreated with oral conjugated equine estrogen (CEE) (premarin®) 0.625 mg daily for twomonths. Twenty postmenopausal women were served as control and received daily doseof placebo.Results: In postmenopausal women treated with conjugated equine estrogen, serum totalcholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were decreasedsignificantly as compared with placebo, while there was no significant change in theserum level of high-density lipoprotein cholesterol(HDL-c). In both groups, estrogeninduced changes in plasma triglyceride and reduced the size of LDL particles. Theseobservations suggest that the plasma TG increase may reduce the size of LDL particle.CEE lowered blood pressure, decreased fasting blood sugar and increased BMI ofpostmenopausal women . Significant positive correlation was found between the BMIand total blood cholesterol whereas significantly negative correlation was found betweenthe BMI and LDL of treated postmenopausal women. CEE effectively alleviatedbothersome symptoms of postmenopausal women such as hot flushes, night sweat andvaginal dryness. Whereas, it has no detectable effects in attenuating bone pain.Conclusion: CEE causes change in lipid profile, BMI, blood pressure and attenuatesbothersome symptoms in postmenopausal women.