Cerebrospinal fluid cholinesterase activity in children with meningitis


Objective: To assess the changes of cerebrospinal fluid (CSF) acetyl cholinesterase(AChE) activity in children with acute bacterial meningitis in comparison to healthyage and sex matched controls.Patients and methods: Out of 41 cases admitted to Alkhansaa pediatric and diliveryhospital (Mosul city) between January 2010 and July 2010, 28 cases proved to be acase of Haemophilus influenzae meningitis, 13 child proved lack from any type ofmeningitis with age and sex matched subjects taken as a control group. Initially fromall of the studied children (patients and controls) about 5 ml CSF samples were takenand assayed for appearance, leucocytes, red blood cells, sugar, protein and AChEactivities by spectrophotometric method.Results: There were a significant increase in CSF WBCs count, RBCs count, proteinlevels, AChE activity with a decrease in CSF glucose level for children with acutebacterial meningitis in comparison to the control group.Conclusion: There is an important value for measurement of CSF AChE activity forconfidential diagnosis of children with acute bacterial meningitis specially for thosewith equivocal decision by using the traditional parameters.