Effect of Lead Toxicity on Liver of Male Albino Mice Ultrastructural Study

Abstract

Lead is a multi targeted toxicant causing effects in different organs of the body. The present ultrastructural study was undertaken on the hepatic tissue of male albino mice.Two groups of male albino mice, 6 animals each were used. The treated group was exposed to 0.25% lead nitrate in drinking water for 4 months,and control group, in comparison with respective control mice. Chronic exposure to subtoxic doses of lead produced ultrastructural alterations in hepatocytes involving mitochondria, endoplasmic reticulum, lysosomes and nuclei. The present study shows chronic exposure to low subtoxic doses of lead, it can induce adverse subcellular alterations in the hepatic tissues.