Synthesis and Study the Biological Activity of Some New Isoxathiozolidines by 1,3-Dipolar Cycloaddition of Nitrones and Thioacetamide


A series of new isoxathozolidines (4-6) were synthesized by 1,3-dipolar cycloaddition reaction of different nitrones with thioacetamide under reflux condition . The yields of products following recrystallization from various solvents, and characterized by spectral methods (IR , UV , TLC , M.P), were used for identification of these compounds. The biological activety show that the compounds have antibacterial activity.