ESTIMATION CELL MEDIATED IMMUNITY IN SOME IRAQI PATIENTS WITH TYPE 1 AND 2 DIABETES MELLITUS

Abstract

Cell-mediated immunity was estimated in diabetic patients by evaluation a level of CD4 and CD8 in type 1 and 2 diabetic patients. Of the 33 patients with type 1 diabetes mellitus 17 were males and 16 were females, as well as the type 2 diabetes mellitus patients were made up of 17 males and 16 females. Both groups attend the outpatient Clinic in the National Diabetes Center, Al-Mustansiriya University. Besides that, the results of this study recorded that the mean of age among patients with type 1 diabetes mellitus was 23.42 ± 4.25 y whereas mean of age among second group was 51.27± 7.83 y with highly significant difference was noticed between them. In addition, the result of this study indicated that duration of disease among type1diabetic patients was 7.15± 2.55 y while 11.45± 6.49 y among second group with highly significant difference was noticed between them. For CD4 lymphocytes, there was a highly significant decrease (P<0.001) in the percentage means of the CD4 cells in type2 diabetic patients, as compared with type 1 diabetic patients. For CD8 lymphocytes, there was a decrease in the percentage of these lymphocyte in the peripheral blood of the type 2 diabetic patients, as compared with type 1 diabetic patients with highly significant importance was recorded between them. In conclusion, this study proved that impaired cell mediated immunity is prevalent in type 2diabetic patients, thus the change level of cytotoxic T-lymphocytes (CD8) and helper T- lymphocytes (CD4) might be responsible for depressed immune response in patients with type 2 diabetes