Abstract

L-Arginine has hypoglycemic and antioxidant effect in Alloxan diabetic animalsand reduce effect of diabetes complication on spermatogenesis. antioxidant haveessential effect on spermatogenesis, L-Arginine has antioxidant and hypoglycemiceffect. Enhanced oxidative stress and changes in antioxidant capacity are consideredto play an important role in the pathogenesis of chronic diabetes mellitus.Sixteen mature male rats aged 10 weeks ,were randomly divided into four equalgroups as follows 1st diabetic group (DG) that received 150 mg/kg (IP) Alloxansingle dose ;2nd group diabetic group treated with (L-Arginine-Hcl)(DAG) received150mg/kg (IP) Alloxan as single dose plus L-Arginine-Hcl 200mg/kg(IP)-per day, 3edgroup treated with(L-Arginine-Hcl)(AG) received 200mg/kg-(IP) perday ,and 4th werecontrol group(CG) non treated .In 60 day the blood samples collected from heart tomake serological parameters (glucose level) and testes removed to observe theirHistopathological.Serum Glucose concentration showed a significant increase (p<0.05) in diabeticgroup (DG) compared with other groups while diabetic treatment group that hasreceived L-Arginine 200 mg/kg(IP) (DAG) showed a significant (p<0.05) decreasecompared with (DG).

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The article was added to IASJ on 2012-09-06

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