Type 2 Diabetic Nephropathy in Uncontrolled Patients Treated with Daonil® and Glucophage®

Abstract

Type 2 diabetes mellitus is similar to type 1 and other forms of diabetes in that it is defined by high levels of plasma glucose and is associated with many long-term complications caused or enhanced by hyperglycemia and related metabolic abnormalities. Levels of glucose,glycohemoglobin(HbA1c),insulin, insulin resistance, ,creatinine , urea, eGFR, microalbominurea ,β2-microglobulin concentraions in sera ,blood, and urine of 298 patients diabetes mellitus treated with daonil(149) , glucophage (149) and 83 apparently healthy who served as control. The results showed a highly significant increase p<0.001 in glucose, HbA1c, insulin, insulin resistance , albumin , creatinine ,microalbominurea, concentrations in patient with diabetes mellitus treatment with daonil and glucophage (less and more than 5y) when compared to control group. Also a highly significant increase p<0.001 of urea, eGFR, β2-microglobulin concentrations(more than 5y).β2-microglobulin concentrations a significant increase p<0.05 in the urine(≤ 5y).