The Influence of Body Weight on the Serum Sialic Acid Levels in Lymphoma Patients

Abstract

the a prospective study of the effect of body weight of 70 patients withlymphoma on the levels of serum sialic acid forms, total sialic acid, boundsialic acid, free sialic acid and lipid sialic acid were measured. The resultswere compared with those obtained from control groups which consisted of 50 personof matched age and sex.Objective: To determine the influence of body weight on the serum sialic acid forms.Methods: The patients were categorized into four groups according to the certainstatistical methods. The first group comprised 24 patients who have weight 5-20Kgrange. The second group comprised 13 patients who have weight 21-40Kg range. Thethird group comprised 12 patients who have weight 41-60Kg range. The fourth groupcomprised 21 patients who have weight >60Kg.Results: Significant elevations (P<0.005) of total sialic acid, bound sialic acid, freesialic acid, and lipid associated sialic acid (TSA, BSA, FSA, and LSA respectively)levels were seen in all groups of lymphoma patients when compared with those of thehealthy subjects. Total serum protein was decreased significantly (P<0.005) andTSA/TP, BSA/TP, FSA/TP, and LSA/TP ratios raised significantly (P<0.005) in thecancer patients in comparison with those of the healthy individuals.Conclusion: Sialic acid is not specific marker for detecting lymphoma patients.Keywords: Body weight, lymphoma patients, serum sialic acid