EFFECT OF LIDOCAINE , DICLOFENAC AND THEIR MIXTURE ON SOME BLOOD PARAMETERS IN EXPERIMENTAL MICE

Abstract

The study included the evaluation of tire haematological effects resulting fromintramuscular injection of ( 1 mg/kg ) of Li! ocaine (group A) , Diclofenac (group B)and Lidocaine — Diclofenac mixture (group in experimental mice , as a result therewas a significant decrease in haemoglobin dpncentration and reached it's lowest valuein group C ( 7.04 gm/100ml ) . There was also a significant increase in both totalWBCS cpunt and eosinophils number reached it's highest number in group C ( 9.88 X103/mm’ , ll.2 % ) respectively , while the highest number basophils appeared ingroup B and reached ( 8 % ) , the same group showed a significant decrease inneutrophils number which reached to ( 17.6 % ) . the a granulocytes ( lymphocytesand monocytes ) showed no changes in number in all groups .