STUDYTHE EFFECT_ OF THE ANTIHYPERTENSIVE DRUG (TENORMIN) ON SOME BLOOD CHARACTERISTICS AND ON THE ACTIVITY OF ISOLATED LEUKOCYTES MEASURED BY CHEMILUMINESCENCE

Abstract

tenormin (atenolol) orally daily for more than three years. The other This study had beendone on thirty blood samples drown from thirty men between 40-60 years of age half of themsuffering from hypertension and taking 100mg fifteen men were healthy and did not takingany drug and regarded as control. Those blood samples were subjected to study somehematological parameters such as hemoglobin percentage and total erythrocyticr andleukocytic counts. Also isolation of leukocytes was done from both hypertensive patient andcontrol and study their activity by chemiluminescence method.v Result showed that prolonged treatment by tenormin of 100 mg orally daily resulted insignificant decrease (P < 0.0l)in total erythrocytic and leucocytic counts as well as the samesignificant decrease in hemoglobin percentage as compared with controls , it also resulted insignificant inhibition of activity of isolated leukocytes as measured by chemiluminescencetechnique which resulted from their weak reaction with the luminescence material(lucigenin)mixed with it in the measuring chemiluminescence apparatus which is an indicationof reduced immunological ability of those leukocytes in addition to their decreased number.