THE CONTRACTION EFFECT OF ALL] UM PORRUM SEEDS ON ISOLATED INTESTINE OF RABBITS

Abstract

Greater attention has been paid to the traditional medical practices in general andherbal medicine in particular even in the developed countries. This study aimed toinvestigate Allium porrum seeds for its potential contraction or relaxation effect on smallintestine in rabbits by using organ bath in vitro. In order to establish a dose-responsecurve for the plant, six male rabbits were used in the experiment.Pharmacological studies of the plant were done by comparing between intestinalcontraction after addition of the plant alone as agonist, and intestinal contraction after theaddition ofboth antaigon”ist’iidrugs then the plant extract.A Allium porrum, showed a statistically significant dose-depend increase of intestinalcontraction.Atropine, adrenaline, and chlorpheniramine reduce the effect of A. porrum onintestinal contraction. Both cholinergic and adrenergic mechanisms may involve theaction of the plant with more potent muscarinic action