Effects of Soybean Seed on Glucose Levels, Lipid Profiles and Histological Structures of the Liver in Alloxan-Induced Diabetic Albino Rats


The effects of soybean seeds on glucose levels, lipid profiles and histological structure of the Liver were investigated. For this purpose, forty male albino rats were divided into four groups each of 10 rats, as following (G1): Normal control rats, (G2): Diabetic rats which injected with alloxan (150 mg/ kg), (G3): Normal rats were treated with soybean seeds at 20% of daily food, (G4): diabetic rats were treated with soybean seeds at 20% of daily food. All treatment was once daily and lasted for four weeks. The animals were taken then collect blood by heart puncture, and scarified directly; then liver was taken. Serum glucose concentration increased significantly (P <0.05) in diabetic rats. Soybean treatment decreased the elevated glucose concentration significantly (P<0.05) in treated diabetic rats; however, their glucose concentrations were still significantly higher (P<0.05) than those of the control group. Induced diabetes by alloxan lead after four weeks to a significant increase in levels of cholesterol, triglyceride, low density lipoprotein, and total lipids, with decreased significantly both body weight and high density lipoprotein. Administration of soybean seeds resulted in a significant increase in body weight with a reduction in levels of triglyceride and low density lipoprotein. Histopathological changes on liver of G2 showed fatty change in hepatocyte,While there is no histopathogenic effect except moderat prolifiration of kuppfer cell in the section of G3, also Section of liver of G4 Showed, no pathogenic effect, and removing of fatty change.