Construction and Charactrization of Chloropromazine hydrochloride Selective Electrode Based on Complex Chloropromazine hydrochloride – Sodium tetra phenyl borate on a PVC Matrix .
Abstract
Chloropromazine hydrochloride selective electrodes were construct based on a complex chloropromazine hydrochloride-sodium tetra phenyl borate as an active material using the plasticizers: di-butyl phthalate(DBPH),O-Nitro phenyl octyl ether (o-NPOE) in a PVC matrix membrane. The properties of the electrodes were studied .A linear range of electrode based on DBPH found from 5×10 -4-10-2 M with a Nernstian slope of 54.1 mV/decade and correlation coefficient of 0.9996,the detection limit was 2 × 10 -4M, and the lifetime was around 72 days. The electrode based on o-NPOE as a plasticizer showed concentration range was 4×10-6-10-2M ,the slope of 50.7 mV/decade with correlation coefficient 0.9994 and detection limit equals to 2.5×10-6M, life time was 52 days. From these results showed that the electrode was successfully applied to the determination of chloropromazine hydrochloride in pharmaceutical preparation.
Keywords
Chloropromazine hydrochloride selective electrode, chloropromazine hydrochloride determination, sodium tetra phenyl borate, plasticizers.Metrics