Chloramphenicol controlled release from Poly(acrylic acid-co-methyl methacrylate)hydrogels

Abstract

In the present work methyl methacrylate-co-acrylic acid (MMA-co-AA) hydrogels were synthesized by free radical copolymerization of methyl methacrylate (MMA) and acrylic acid (AA) using methylene bisacrylamide (MBA) as crosslinker, potassium persulfate (KPS) and sodium metabisulfite (SMBS) as a type of mixed redox initiators. Selected samples were loaded with model drug chloramphenicol. For the chloramphenicol release, the effect of pH, monomeric compositions, degree of crosslinking were investigated. The release of chloramphenicol was studied for 11 day period in phosphate buffer solutions of different pH 2, 4, and 7.2. The swelling ratio (Rs) was measured for all the hydrogel structures, in three different media (pH=2), (pH=4) and (pH=7.2), and three different temperatures (37, 45, 50 ) 0 C as function of time. The results showed that drug release increased by decreasing (MMA) content in the hydrogels