EFFECT OF VITAMIN B6 TO RELIF COPPER SULFATE TOXICITY ON SOME PHYISOLOGICAL AND HISTOLOGICAL PARAMETERS OF FEMALE RABBITS

Abstract

1EFFECT OF VITAMIN B6 TO RELIF COPPER SULFATE TOXICITY ON SOME PHYISOLOGICAL AND HISTOLOGICAL PARAMETERS OF FEMALE RABBITSZAINAB A. H. AL-MOUSAWI1, ABDULKAREEM A. BABE2, NABEEL M. ABED31, 3 Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Basra2 Departments of Animal Production, College of Agriculture, University of BasraAbstractThe present study was undertaken to investigate the role of vitamin B6 in the improvement of the copper sulfate toxicity on some hematological parameters, biochemical parameters and histopathological changes in some internal organs of female rabbits. Eighteen female rabbits were divided to three groups(6 rabbit for each group) .The first group treated with normal saline orally daily for10 days (control),the second group treated with 6mg/kg live weight copper sulfate orally, and third group treated with 6mg/kg live weight copper sulfate orally and7mg/kg live weight vitamin B6 intramuscular injection daily for10 days .The results showed positive effect of vitamin B6 to improvement the different changes which resulted from the exposure to copper sulfate .There was significant increased PCV, Hb concentration and RBC count in third group when compared with second group .Total WBC count percentage improvement and decrease significantly total cholesterol ,ALT and AST in third group when compared with second group .In addition to that the histopathological changes in liver and kidney were return to the normal value with a little alteration as compared with control group.