In vivo lung injury caused by Pseudomonas aeruginosa DNA


Noticeable inflammatory reactions in rats lungs were caused by DNA isolated from Pseudomonas aeruginosa include infiltration of macrophages, neutrophiles and lymphocytes. Additionally, fibromuscular hypertrophy of smooth muscles in respiratory bronchiols was seen as well. Since lung homogenate shows no bacterial growth in all samples. Consequently, these inflammatory signs were attributed to DNA effect rather than any other cause. In conclusion, apart from live bacteria, P. aeruginosa DNA has the ability to cause inflammatory response in rat model airways.