IL-6 and Type 2 Diabetes

Abstract

Summary:Background: Interleukin -6 (IL-6) as the key mediator of the acute phase reaction is of interest .elevated protein concentrations of IL-6 in the blood have been shown in patients with type 2 diabetes. This study aimed to investigate the association of IL-6 and type 2 diabetes.Materials and Methods: Blood samples were collected from 40 patients with type 2 diabetes and 40 person apparently healthy control were examined for IL-6 level by Enzyme Linked Immune Sorbent Assay. HbA1c determined by high pressure liquid chromatography .total cholesterol, HDL cholesterol and triglyceride were determined enzymatically. Other risk factors study like age, sex and BMI. Results: results shows that IL-6 was higher in patients than in control (p<0.006) and there is significant increase in triglyceride. HbA1c shows high levels in diabetic patients (mean 6.855±1.57%) than the healthy control (mean 4.650±o.673) and when comparing the three diabetic BMI groups with healthy control a significant higher serum IL-6 level was found p=0.008 in over weight group .Conclusion: there is a significant elevation in serum IL-6 in type 2 diabetics when compared to healthy controls and there is a significant elevation of IL-6 in over weight.Key words: Interleukin -6, Type 2 Diabetes, Hemoglobin A1c, Body Mass Index.