Modification of Poly(vinyl chloride) via introducing of pendent thiadiazole derivatives and study their Biological Activity

Abstract

The present work consist of modification of poly (vinyl chloride) by introduce of pendent thiadiazole which mercapto and amino groups were synthesized in this work according to the following: 1) Reaction of PVC with 2-amino-5-thiol-1,3,4-thiadiazole [I] in THF solvent afforded the following modified polymer (P1) 2) Treatment of PVC with2-Amino-5-ethyl thio-1,3,4-thiadiazole [II] in THF solvent furnishes the modified polymer (P2) 3) Reaction of PVC polymer with 2[4-dimethyl amino benzylidine] 5-thiol- 1,3,4-thiadiazole yields the modified PVC polymer (P3) Structures of all these thiadiazole deravitives and modified polymers have been confirmed by spectral ( FT-IR,UV and H-NMR) analysis. The newly synthesized compounds were subjected to in vitro against two strains of pathogenic microorganism Staphylococcus arueus and Escherichia coli