Study of Prostate Specific Antigen and gamma-Glutamyltranspeptidase in Human Prostate Cancer

Abstract

The study included 30 patients of prostate cancer and benign prostatehyperplasia and 10 healthy men as control. They were evaluated for seralevels of tumor marker PSA (IRMA) and GGT before any type of therapy orsurgery. The mean values for 15 patients with PCa and 15 patients with BPHgroup were: a) PSA: 62.5±9.426 and 9.36±3.55 ng.ml-1 respectively; b)GGT: 94.3±9.98 and 80.5±11.5 IU.L-1 . A significant increases (p<0.001)was observed in PSA levels and (p<0.002) in GGT levels in benign prostatehyperplasia as compared to normal control subjects. Patients with prostatecancer show increases in mean of PSA and GGT levels as compared tonormal control subjects (p>0.05). A significant positive correlation wasobtained between PSA and GGT (p<0.001) in prostate cancer and benignprostate hyperplasia.