Antibacterial efficiency of salvia officinalis extracts and their effect on growth, adherence and acid production of oral Mutans Streptococci


Background: The use of antimicrobial agent to control plaque and oral disease has been advocated for a number ofyears. Different compounds have been delivered through mouth rinses or tooth pastes or by topical application. Thepurpose of this research is to find out and to compare between the anticariogenic properties of aqueous and alcoholicsage extract on the most causative cariogenic bacteria in the oral cavity (Mutans streptococci).Materials and methods: In the present study Mutans streptococci were isolated from saliva often dental students (agerange between 21-23 yrs) .These bacteria were isolated, purified and diagnosed according to morphologicalcharacteristic and biochemical tests.Results: Agar diffusion technique showed that sage extracts (aqueous and alcoholic) were inhibited the growth ofMutans Streptococci, and the diameter of inhibition zone increased as the concentration of sage extract increased, butthe effect of aqueous extract was less than the effect of alcoholic extract. The minimum bactericidal concentration ofaqueous and alcoholic sage extract were 50%, 20% respectively. Also the alcoholic extract was high significant inhibit(P<0.01) the viable count of Mutans Streptococci in vitro in comparison to aqueous extract.Conclusion: Alcoholic sage extract was interfered with acid production and adherence of Mutans Streptococci higherthan aqueous extract resultant in reducing of acid production and inhibition of the adherence of this cariogenicbacteria; alcoholic sage extract have substantively phenomenon similar to those in chlorohexidine in comparison toaqueous extract