Serum and Erythrocyte Magnesium Levels in Patients with Myocardial Infarction with or without Heart Failure


BACKGROUND :Magnesium (( Mg(1) )) is a mineral that is involved in over 300 reactions in the body. Magnesium is aPotent vasodilation ,and plays an important role in muscle contraction. It has been earlydocumented that Mg deficiency can precipitate ventricular arrhythmias and treatment with Mg hassome anti arrythmic effect. Moreover there is an ample evidence that a significant percentage ofpatients with IHD suffer from Mg. The risk of IHD increaseswith age, smoking, hypercholesterolaemia,diabetes mellitus, hypertension(1). Ischemic heartdisease presented as stable angina , unstableangina , myocardial infarction , ischemic heartfailure and ischemic cardiomyopathy. Thediagnosis of ischemic heart disease depend onclinical history and investigation including: *Ministry of Health AL-Bitar Hospital,Baghdad.Iraq.**Biochemistry Dept. Collage of Medicine University of Baghdad.*** Dept. Baghdad Medicine City. deficiency.OBJECTIVE : The objective of the present study is to measure Mg(2) levels in serum and RBCs of patients withsome forms of IHD. PATIENTS AND METHODS:The study was conducted in Baghdad hospital and Ibn – Al-Bitar Hospital.The 180 patients withIHD were divided into Two groups. Group I, 80 patients with Ischemic Heart Failure (IHF)(EF˂30) aged 65.75±5.97 year (50 males and 30 females), group II, 100 patients withMuocardial Infarction (MI)(EF˂50) aged 50.34±6.36 year (58 males and 42 females). Serum Mg and RBCs Mg weremeasured in all patient groups by Atomic Absorption Spectrophotometer.RESULTS: The(mean ±SD) value of serum and RBCs Mg in patients with both groups Ischemic Heart Disease(IHD) was significantly lower when compared with that of controls (p<0.05).The serum Mg levels (0.81±SD mmol/L) are significantly lower in the IHF group and in MI group (0.96±0.18 mmol/L)when compared with that of controls (1.00±0.17 mmol/L) (p˂ 0.001).CONCLUSION: The data obtained in present study revealed the decrease of Mg level in serum and RBCs in bothpatients groups, which affect the contractility of heart muscle and cardiac performance