Studying The Toxicity Effect of Hydroxyurea on The Spleen of Male Albino Mice

Abstract

Hydroxyurea (HU) is one of many drugs that used for cancer treatment such as Leukemia, previous studies have been shown the side effects of hydroxyurea which occurred during treatment, studying the potential toxicity of this drug on the spleen (one of the major organs of immunity) have not been taken by consideration, therefore the present study designed to reveal the effects of hydroxyurea on the splenic tissue. The present study have shown several histopathological changes in splenic tissue which then effect on the functions of spleen as a result of the potential toxicity of hydroxyurea on spleen.