Evaluation of the Effect of ACE Inhibitor Therapy on Diastolic Dysfunction in Hypertensive Patients

Abstract

To investigate the effect of optimal control of blood pressure by ACE inhibitor (Captopril) on diastolic dysfunction 100 hypertensive male patient with mean age 3815 years and 100 normal subjects. The left ventricular diastolic function were evaluated by Echo. study and show diastolic dysfunction in hypertensive patient according to E/A (E: early diastolic velocity, A: Late diastolic velocity with atrial contraction) and isovolumic relaxation time (IVRT), declaration time (DT) the study show reverse E/A ratio, prolong IVRT and DT in hypertensive patient and normal diastolic function in control subject we fallow these patient for three months and we reevaluate left ventricular diastolic function were the result still same and diastolic dysfunction still present after three months of good control hypertension with ACE inhibitor drugs. (Captopril