The Antimicrobial Activity and the Median Lethal Dose of Thyme (Thymus vulgaris) Ethanolic Extract on Mice

Abstract

Abstract:The antimicrobial activities of thyme (thymes vulgaris) ethanolic extract was studied byagar well diffusion technique against tested organisms (Esherichia coli, Staphylococcusaureus and Candida albicans). The results were showed that the extract have antibacterial andantifungal activity against tested microorganisms. The results were also showed that themedian lethal dose (LD50) of ethanolic extract of thyme in laboratory mice was about (4220mg/kg B.w). The toxic signs during 24 hours after oral administration of thyme extract wererapid breathing, dullness, contraction of abdominal muscles, paralysis then death.Key words: Thyme, Antimicrobial activity, LD50