Relation of Oxidant-Antioxidant Status with Glycemic control in type 2 diabetic patients


Abstract:In diabetes mellitus, persistence of hyperglycemia was reported to cause increasedproduction of oxidative parameters, and decreased antioxidant status. Therefore, the presentstudy considered to evaluate the effect of glycemic control on oxidant-antioxidant status in type2 diabetic patients. The study examined 145 type 2 diabetic patients, who attend to the NationalDiabetic Center (Al-Mustansiyriah University). Patients were divided in two groups, as wellglycemic controlled (group1[75 patients]) (HbA1c< 7%, and FSG < 110 mg/dl) and poorlycontrolled (group2 [70 patients]) (had HbA1c≥ 7%, and FSG ≥ 110). All patients were reported inthe morning after overnight fast, and underwent physical examination and laboratory tests.Height and weight were noted for Body Mass Index (BMI), it was calculated as weight(Km)/height2 (m2).Laboratory evaluations consisted of measuring fasting serum glucose (FSG), glycatedhemoglobin (HbA1c), total cholesterol (TC), triglycerides (TG), malondialdehyde (MDA),erythrocyte-Glutation (GSH), ascorbic acid (AA), uric acid (UA), and cerulopalsmine (CP). Theresults indicate that fasting serum FSG, HbA1c, (MDA), (TC), and (TG), were increasedsignificantly (P<0.01 for FSG, HbA1c, MDA; and P<0.05 for TC, and TC) in poorly controlledsubjects comparing to well controlled. Instead of that there is significant increase in (CP)(P<0.05) in poorly controlled patients. On the other hand there is significant decreased in (GSH,(AA), (UA) (P<0.01 for GSH, AA; and P<0.05 for UA) in poorly controlled compared to wellcontrolled diabetic patients. Correlation analysis showed a significant positive correlation inserum HbA1c-MDA, GSH-AA (P<0.01; and P<0.05 respectively) in both group, while there isonly positive correlation in HbA1c-FSG (P<0.01) in well controlled patients, and positivecorrelation in HbA1c-TC in poorly controlled patients. On the other hand, there is a significantnegative correlation in MDA-GSH, MDA-AA, and MDA-UA in both studying group. Thepresent study concludes the increased risk of oxidative stress manifested by increased plasmaMDA, and decreased antioxidant levels in poor glycemic control. The study therefore suggests,the estimation of antioxidants levels with other routine investigations may be useful in reduce ofthe oxidative stress in diabetics.