Vitamin C, an Antioxidant Attenuates Gentamicin-Induced Acute Kidney Injury in Female Albino Wister Rats

Abstract

We investigated the effect of vitamin C against acute kidney injury(AKI) in female Albino Wister rats. AKI was produced by gentamicin as a simple method for induction AKI, so this achieved by injection of gentamicin as single dose [100mg/kg intra peritoneal (I.P) a day for 10 days] in rats. Vitamin C (200mg/kg I.P a day) was administered 1hr before AKI induction by gentamicin for 10 days. The blood urea nitrogen(BUN), serum creatinine(Scr) concentrations and Malondialdehyde (MDA) level were markedly elevated in gentamicin-AKI group after treatment 78.05±0.591mg/dl, 1.169±0.017 mg/dl and 85.70±0.587mg/dl (P<0.0001) respectively, but these elevations were significantly suppressed by vitamin C in vitamin C–treated AKI group17.81±0.457mg/dl, 0.724±0.009 mg/dl and 50.30±0.213 nmol/g (P<0.0001) respectively.These findings suggest that vitamin C can protect the renal damage caused by gentamicin.