The role of low level laser therapy on the expression of IL_1 beta in wound healing


Background: Low-level laser therapy (LLLT) has been extensively applied to improve wound healing due to somebiostimulatory properties presented by laser arrays apparently able to accelerate the repair of soft tissue injuries.However, the role of proinflammatory interlukines not been studied yet. IL_1 β represent one of the most importantporoinflammatory interlukines that involved in wound healing. The goal of this study was to investigate the effect of790-805nm diode laser on the expression of IL_1 β during wound healing in mice.Materials and Methods: Standard-sized wounds (1.5cm) were carried out in the face of 96 white albino mice. Half ofthem underwent LLLT treatment (360 J/cm 2) at 790-805 nm delivered immediately after wound procedure. Therepairing area was removed and stained with immunohistochemistry technique to detect the expression of IL_1 β.Results it had been found that LLLT was able to increase the expression of the IL_1 β in early phases of healing as wellas to enhance epithelization remodeling process at both 7 th and 14 th days of wound healing.Conclusions : The LLLT protocol tested in this study resulted in increased the expression of IL_1 β in the lased groupsignificantly at day 7 of healing period which affect wound healing