Immunohistochemical expression of E-cadherin and CD44 adhesion molecules in oral squamous cell carcinoma

Abstract

Background: Head and neck squamous cell carcinoma is the sixth most common cancer world wide. Despitegreater emphasis on multi-modality therapy including surgery, radiation and chemotherapy, advanced stage headand neck squamous cell carcinoma continues to have poor 5-year survival rates (0-40%) that have not significantlyimproved in the last (30) years. To improve outcomes for this deadly disease , It is required a better understanding ofthe mechanisms underlying head and neck squamous cell carcinoma tumor growth, metastasis, and treatmentresistance. This study evaluates the Immunohistochemical expression of E-cadherin and CD44 adhesion molecules inOSCC and to correlate the expression of either marker with each other, with lymph node metastasis and with tumorgrade.Materials and methods: Thirty blocks of OSCC were included in this study. An immunohistochemical staining wasperformed using anti E-cadherinand anti CD44 monoclonal antibodies.Results: Negative immunohistochemical expression of E-cadherin was found in(66.7%)of the cases and only(33.3%)revealed positive immunoexpression. Positive CD44 immunoreaction was seen in(86.7%)of the cases. Therewas no statistically significant correlation regarding either marker with respect to the tumor stage, grade and lymphnode matastasis. Moreover anon-significant correlation was found between the expression of both markers.Conclusions: this study revealed negative E-cadherin expression in two thirds of the cases, while positive CD44 wasillustrated in most of them. Non- significant correlation was found regarding the expression of both markers with tumorstage, grade and lymph node status. Inverse significant correlation was found regarding CD44 expression with theclinical presentation of the study sample. In addition, non significant correlation was found between the E-cadherinand CD44 immunoexpression