The Effects of Organophosphorus Insecticides on Liver of Male Mice


Background: Pesticides cause ecological problems which may result in immediate mass mortality and biological magnifications.Objectives: To study the effect of organophosphorus on liver of male mice.Material and Methods: Male Balb/c mice weighing 30-35 gm, 60 days old, were treated orally with monocrotophos(1/3 LD50,1.8 mg/kg bw) and methyl parathion (1/3 LD50 ,2.8 mg/kg bw) for 30 days. The liver weight, and aminotransferase, acid phosphatase and alkaline phosphatase in homogenates were estimated.Results: The present study revealed the levels of acid phosphatase, alkaline phosphatase, aspartate aminotransferases and alanine aminotransferases, were significantly (p<0.05) increased in liver with all of the two organophosphates.Conclusion: It has been concluded that (monocrotophos and methyl parathion) caused increased in the levels of phosphatase and aminotransferase as well as decreased in liver weight.