Association between serum leptin level and acute myocardial infarction

Abstract

Objective: To assess the relationship between serum leptin level and acute myocardial infarction in patients who received thrombolytic therapy. Methods: Fifty patients with acute myocardial infarction (mean age:58.16±11.73 years)at first 12 hours of admission and thirty four normal control group (mean age: 53.98±15.46 years) matched for age ,sex and other risk factors were enrolled in this study, serum level of cardiac troponin I was measured in patients and control group( mainly for diagnostic purpose),two readings were obtained for the patients( one at admission and 6-9 hours later).The patients were followed up clinically during entire hospitalization period to assess patients response to thrombolytic therapy as well as for the development of any complication, Serum level of leptin also measured in the first 12hour in both groups. Results: The study showed that serum leptin level in patients with acute myocardial infarction(mean 10.03ng /ml) was significantly higher than that of control group (mean 6.97ng/ml), p value <0.0001. Conclusion: The present study showed that higher serum level of leptin was associated with occurrence of myocardial infarction as etiological factor or sequel.