EFFECT OF METRONIDAZOLE (FLAGYL) ON RBC, WBC AND ACTIVITY OF THREE ENZYMES IN THE BLOOD SERUM OF ALBINO FEMALE MICE

Abstract

Metronidazole is a drug used against bacteria and protozoa in the body. The toxicity of metronidazole to kidney ,liver and other organs has been shown in some studies. The purpose of this study was to examine the effects of metronidazole (200,400 and 600 mg/kg /day) with drinking water for 45 days on some blood parameters in mature female mice (albino). Metronidazole caused a significant decrease in RBC,WBC and in the activity of Alkaline phosphatase , and caused a significant increase in the GOT activity.