Cytotoxicity–Associated gene (CagA) Producing Helicobacter pylori Increased Risk of Developing Colorectal Carcinoma in Iraqi Patients.


Abstract:Infection with Helicobacter pylori, particularly with strains positive for cytotoxicity–associated gene (CagA) gene, increases the risk of gastric adenocarcinoma and it may beassociated with carcinogenesis in extra gastric target organ. The aim of this study to explorethe possible association between CagA positive H. pylori and colorectal carcinoma anddetermine the association with clinico-pathological features.Paraffin embedded tumor specimens from (49) patients with colorectal adenocarcinomaand (30) healthy control were assessed by in situ hybridization for the expressionof H. pylori CagA mRNA.Statistical analysis of H. pylori CagA positive expression revealed highly significantdifference in colorectal carcinoma patients than in control group. There was no relationshipbetween H. pylori CagA positive expression and range of clinicopathological features.Among patients infected with H. pylori CagA positive is associated with increased risk forcolonic cancer.