Synthesis of New Azomethine-N-oxide compounds and Study of Their Antifungal andAntioxidant Activities


In the present research two nitrones, azomethine-N-oxides, were synthesized. The structures of the synthesized compounds have been confirmed on the basis of elemental analysis, FT-IR, 1H-NMR spectral studies. The nitrones were screened for their antifungal activity against Asperigillus niger and Aspergillus flavus and the zone of inhibition was determined by disc diffusion technique. Both nitrones exhibited promising antifungal activity against fungi as compared with standard drug. The antioxidant properties for the synthesized nitrones were studied by using two in vitro models, such as conjugated diene and reducing power systems. From the results, found that both nitrones have good antioxidant activity compared with using the control, α-tochopherol.