Effect of increase thyroid hormone on antioxidant enzymes activity and their related metals in hyperthyroid patients in Basrah Governorate/Iraq.


The maintenance of optimal health requires an adequate supply of carbohydrates, proteins lipids, macronutrients, micronutrients, and trace elements. The present study evaluates the increase of thyroid hormones (hyperthyroidism) on antioxidant enzymes including superoxide dismutase, glutathione peroxidase and the levels of zinc, copper and selenium in serum of Iraqi patients with hyperthyroidism .The results showed a significant increase (p≤0.05) in erythrocyte superoxide dismutase (SOD) activity in patients as compared with control group. While there is a highly significant decrease (p<0.001) in glutathione peroxidase activity in patients as compared with controls. The levels of zinc and selenium were highly significantly decrease in hyperthyroid patients compared with control with no significant change (p>0.05) in concentration of copper in patients group compared with the control group. The results indicated that hyperthyroidism increased the free radicals due to decreasing the free radicals scavengers.