Synthesis and Antimicrobial Activity Study of Several New Pthalimides Linked to Drugs Molecules


In this work several new phthalimideslinked to drugs moleculeswere synthesized. Drug molecules used in these syntheses include four β-lactam antibiotics namely(Ampicillin,Amoxicillin, Cefadroxil, Cefotaxime) and two vitamins namely (Thiamine and folic acid).Some of the new phthalimides were synthesized via two steps in the first one several phthalamic acidslinked to Drug Molecules were synthesized via reaction of phthalic anhydride with(Ampicillin,Amoxicillin, Cefadroxil, Thiamine). The resulted phthalamic acids were dehydrated in the second step via treatment with acetic anhydride and anhydrous sodium acetate producing the target phthalimides.The other target phthalimideswere synthesized via direct fusion of the mixture of phthalic anhydride and drug (Cefotaxime or folic acid).The new phthalimides were screened for their antimicrobial activity against four types of bacteria and Candida albicans fungi and the results indicated that the new phthalimides exhibit good inhibition effect against the tested organisms.


Pthalimides, Drugs.