Study of Some Miswak (Salvadora persica L) Components and Effect of Their Aqueous Extract on Antioxidant


ABSTRACT:BACKGROUND: Oxidative stress defines that, the level of Reactive Oxygen Species (ROS) exists in excess of antioxidant defenses. This imbalance in the redox milieu results in a switch from ROS-stimulated ambient signaling processes to ROS-mediated pathophysiological consequences. Oxidative stress has been implicated in the installation and progression of several degenerative diseases via DNA mutation, protein oxidation and/or lipid peroxidation. Therefore, possible use aqueous extracts of Miswak to protect brain against the Lipid peroxidation.OBJECTIVE: The present study was undertaken to evaluate the potential of Salvadora persica L. (miswak) against the DPPH Free Radical Scavenging System and Lipid peroxidation.METHODS: The chemical components of the prepared aqueous extracts of Miswak were detected as: glycosides, alkaloids, saponins, phenolic compounds, tannins, flavonoids , proteins ,steroids and Vitamine C. and then estimate DPPH Free Radical Scavenging System and Lipid peroxidationRESULTS: The study showed that the Miswak ( Salvadora persica L.) in the aqueous extracts contain : glycosides , proteins, saponins ,tannins ,phenolic compounds, flavonoids , alkaloids , steroids and vitamine C . Aqueas extracts were found effective in scavenging DPPH(62.45℅) in concentration (250µl/ml), as well as inhibiting the lipid peroxidation (42.04℅). CONCLUSION: Our results suggest that Miswak ( Salvadora persica L.) treatment protects the rat brain against lipid peroxidation and DPPH free radical scavenging..