SYNTHESIS, CHARECTERIZATION AND ANTIOXIDANT ACTIVITY OF BIS [4-(4'-HYDROXY-3'-METHOXY BENZYLIDENE AMINO PHENYL)] TELLURIDE

Abstract

Bis[4-(4'-hydroxy-3'-methoxy benzylidene amino phenyl)] telluride (R2Te) was prepared from the reaction of two moles of 4-(4'-hydroxy-5'-methoxybenzylidene amino phenyl) mercuric chloride and one mole of TeBr4in dry dioxane to give diorganyl tellurium dibromide (R2TeBr2) which reduced by boiling ethanolic hydrazine hydrate to give the corresponding new telluride (R2Te).R2Te inhibits nitrite induced methemoglobin formation in hemolysate. The time required to convert 50% of the available hemoglobin to methemoglobin was increased from 2.5 to 4, 5.5 and 10.5 minutes by the addition of (1.25, 5 and 20µM) of test compound (R2Te) respectively, and from 7 to 15, 29 and 54 minutes to convert all of the available hemoglobin to methemoglobin. It seems that R2Te failed to inhibit nitrite induced hemoglobin oxidation if added after the autocatalytic stage (5-10 minutes after nitrite addition). R2Te, a novel organotellurium compound, can inhibit nitrite induced methemoglobin formation in hemolysate in a dose dependent manner if added before the autocatalytic stage.