Estimation of Serum Malondialdehyde and Uric acid levels in Smokers and non-Smokers

Abstract

Malondialdehyde (MDA) is one of many low molecular weight end-products of lipid peroxidation; it is as an index of lipid peroxidation. Uric acid is one of the endogenous oxidant-antioxidant paradoxes.The aim of this study is to evaluate the levels of serum MDAand uric acid insmokers and non smokers. This study was carried out from January to July 2012 on (30) smokers and (30) non smokers.Serum MDA level was measured spectrophotometrically using thiobarbituricacid method, whereas serum uric acid was measured using enzymatic colorimetric method.The results of the study revealed a significant increase (P<0.001) in uric acid value in smokers subjects compared to non smokers (6.54 ± 0.37 Vs 4.68 ± 0.22) respectively, while no significant difference (P>0.05)In MDA value was observed in smokers and non smokers subjects (2.227 ± 0.394 Vs 1.912 ± 0.32) respectively.

Keywords

Smoking, MDA, Uric acid.