Synthesis, Characterizationand Antibacterial Activity of Some New Five-Seven Membered Rings AttachedtoSulfonamideCompounds
Abstract
This work includes the synthesis of some new five- seven heterocyclic rings derived from benzenesulfonylhydrazide as starting material. Its condensation with 4-methoxy and 4-nitro benzaldehyde givesthe Schiff bases (1a,b). Schiff bases were reacted with cyclic anhydrides given Oxazepine, Thiazepine derivatives(2,3,4 a,b)(seven membered ring) and with 2-mercapto benzoic acid gives thiazine derivatives (6a,b)(six membered ring) finally with thioglycolic acid give thiazolidine ring(five membered ring) scheme(3). The synthesized compounds have been characterized by melting points,FT-IR,1H-NMR spectroscopy ,13C-NMRand Elemental analysis. some ofsynthesized compounds were tested for their antibacterial activity against staphylococcus aureus,pseudomonous aureousandEscherichia coli.The results showed good efficacy against these types of bacteria.
Keywords
sulfonamide, Oxazepine, Thiazepine, Thiazine, Thiazolidine, Schiff bases, Antibacterial activity.Metrics