Synthesis ,Characterizationand Study Biological Activity of Some New 1, 3, 4-Thiadiazole and PyrazoloneDerivatives Containing Indole Ring


This work involves synthesisand characterization of some new 1, 3, 4-thiadiazole or pyrazolinederivatives heterocycliccontaining indole ring. The new 2-amino-1,3,4-thiadiazole derivatives[IV] and [V]a, bwere synthesized by cyclization reaction of 2-methyl-1H-indole-carbothiosemicarbazide[III] in H2SO4 acid or by reaction ofindole-3-acetic acid orindole-3-butanoic acidwith thiosemicarbazide in the presence of phosphorous oxychloride, respectively. Amide derivatives [VI]-[VIII]were synthesized by the reaction equimolar of 2-amino-1,3,4-thiadiazoles and (acetyl chloride, benzoyl chloride, anisoyl chloride and heptanoyl chloride) in DMF and pyridine as accepter.The newpyrazolonederivatives[XI]a, b were synthesized from heating under reflux equimolarfrom amixture of acid hydrazides [X]a or [X]bandethylacetoacetate in absolute ethanol.Acetyl pyrazolonecompounds[XII]a, bwere synthesized by the reaction ofpyrazolonederivatives[X]aor [X]bwith acetyl chloride in 1,4-Dioxane in present of calcium hydroxide to give 4-acetylpyrazolone derivatives[XI]a, b. Thenew aryl hydrazone derivativesof pyrazoline [XIII]and [XIV]were synthesized by the reaction of one mole of compounds [XII]aor [XII]b with one mole of phenyl hydrazine or substituted phenyl hydrazine in ethanol.All the synthesized compounds have beencharacterized by melting points , FTIR,1HNMR and Mass spectroscopy (of some of theme).