@Article{, title={Synthesis and characterization of some new triazine-1-one derivatives with studying its biological activity}, author={Maysoon T. Tawfiq}, journal={journal of the college of basic education مجلة كلية التربية الاساسية}, volume={20}, number={87 / علمي}, pages={21-48}, year={2015}, abstract={

This work includes synthesis a series of some new derivatives of triazine from reaction between the sulfur amino acid (L-cysteine) and different aldehydes in dry ethanol to obtain thiazolidine ring as diastereo isomers (Cis and Trans)- 2- alkylthiazolidine-4- carboxylic acids (1). The thiazolidine derivatives (1) suffered esterfication reaction of carboxylic acid in presence of drops of concentrated sulfuric acid as a catalyst to give the esters :ethyl 2- alkylthiazolidine -4 - carboxylates (2), which reacted with hydrazine hydrate in (addition- elimination) reaction to give acid hydrazides : 2-alkylthiazolidine-4-carbohydrazides (3). Acid hydrazides (3) were reacted with acetyl chloride by (NH) acetylation reaction to form: 3- acetyl-2-alkylthiazolidine -4 - carbohydrazides (4). The last step includes cyclization reaction of compound (4) to yeild triazine-1-one derivatives (5), which undergo tautomerization phenomena: triazine -1- ol (6). Triazine derivatives were expected to be biologically active. The prepared compounds were characterized by spectral methods (FT.IR, H1NMR, and UV. -Vis.) , melting points and measurement of some of its physical properties ; and the reaction was followed by TLC. Some of these compounds were tested against becteria , Escherchia coli and Staphococcus aureus.Key word: Heterocyclic compounds, Thiazolidine, Triazine ring, Sulfur amino acids .} }