TY - JOUR ID - TI - Interleukine-6 Level in Saliva of Patients with Chronic Periodontitis: A Case-Control Study AU - Haween T. Nanakaly PY - 2016 VL - 28 IS - 1 SP - 103 EP - 108 JO - Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد SN - 18171869 23115270 AB - Background:Periodontal diseases are infectious diseases in which periodontalpathogens trigger chronicinflammatory and immune responses. Interleukine-6 is a multifunctional cytokine playing a central role ininflammation and tissue injury.The aim of the study IS to determine the level of Interleukin-6(IL-6) in saliva of patientswith chronic periodontitis compared to healthy subjects.Materials and Methods:The total subjects of the present study is 60, divided into 3 groups; 20 patients with chronicperiodontitis with pocket depth(PD ≥4 mm)(group I), 20 patients with pocket depth(PD <4 mm) with clinicalattachment loss (group II), and 20 healthy controls with pocket probing depth (PPD ≤ 3 mm) without clinicalattachment loss (group III). Un-stimulated salivary sample was taken from each subject and was investigated for thepresence of Interleukine-6by using Enzyme‑linked Immunosorbent Assay (ELISA) technology.Results:Mean IL-6 levels in saliva in patients with chronic periodontitis (98.40 ± 18.44 ng/L)was significantly higher thanin controls (11.67 ± 3.32; p=0.001). Also a significant difference in IL-6 levels in saliva was observed between the PPD ≥4 mm and PPD < 4 mm groups and between PPD ≥ 4 mm and control groups, as well as statistically significantdifferences were observed between PPD < 4 mm and control groups (P < 0.001).Conclusion:The Interleukine-6 level in saliva can be considered as one of inflammatory biomarker indicators ofseverity of periodontitis

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