@Article{, title={Evaluation of the effectiveness of coenzyme Q10 gel in management of patients with chronic periodontitis (I intra group comparison)}, author={Taif M. Salih and Maha Sh. Mahmood}, journal={Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد}, volume={27}, number={2}, pages={130-135}, year={2015}, abstract={Background: Periodontal pathogens can induce free radicals over-formation and thus may cause collagen andperiodontal destruction. Anti-oxidants are used as supplements to counteract the over production of free radicals inperiodontal disease, that can reduce of collagen destruction. Coenzyme Q10 serves as an endogenous antioxidant,regenerates other antioxidants, stimulates cell growth, and inhibits cell death. Because it is an antioxidant, coenzymeQ10 has received much research attention associated with periodontal diseases. Perio Q gel may possibly beeffective as a topical agent and as an adjunct to scaling& root planing in treatment of gingivitis and chronicperiodontitis.Aim of study:Determine the periodontal health status in a follow up study for 6 weeks of a group of patients withchronic periodontitis by measuring clinical periodontal parameters, which included (Plaque index, Gingival index,Bleeding on Probing, Probing Pocket Depth and Relative Attachment Level) and to evaluate the effect of intrapocket application of perio Q gel (coenzyme Q10) alone & as adjunct to scaling,& root planing on the periodontalclinical parameters in the management of patients with chronic periodontitis.Materials and methods: A total of 323 sites with pocket depth (5-8) mm in patients with chronic periodontitis wererandomly divided in three groups. The Gel group, 111 sites were treated with intra-pocket application of Perio Q gelalone. In the Combination group, 106 sites were treated with scaling and root planning (SRP) plus intra- pocketapplication of Perio Q gel, in Scaling and root planing group, 106 sites were treated with scaling and root planingalone. Clinical periodontal parameters such as Plaque index (PI), Gingival index (GI), Bleeding on probing (BOP),Probing pocket depth (PPD), Relative attachment level (RAL) were assessed at first visit, 3weeks and 6weeks.Results: on intra-group analysis, all groups showed highly significant reduction in PI, GI, BOP, PPD and RAL among thethree visits .On inter-group analysis, the results showed significant reduction in the clinical parameters PPD and RAL ofcombination group in comparison to SRP group.Conclusion: The results of the research were encouraging and suggested the possibility to use the gel as a sole agentto support standard treatment procedures in periodontitis. The clinical parameters significantly improved in the phaseof periodontal treatment, indicating that CoQ10 opens new treatment options by improving the host response todisease activity.

} }