TY - JOUR ID - TI - Antioxidant and Anti-Inflammatory Effect of Fruit Juice of Annona Muricata L (Soursop) During Ischemia Reperfusion Injury in Rats AU - Mustafa Taha Mohammed AU - Sarah Isam Abbas PY - 2016 VL - 15 IS - 1 SP - 118 EP - 123 JO - Iraqi Postgraduate Medical Journal المجلة العراقية للاختصاصات الطبية SN - 83601608 98932708 AB - ABSTRACT:OBJECTIVE:The study included knowledge The chemical components of the Soursop juice and determine whether Soursop prevents ischemia-reperfusion induced brain injuries in rats.METHODS:The chemical components of the prepared fruit extract were detectedits components of glycosides, proteins....etc and we were Determination of trace element and the estimation of the biochemical parameters: Blood samples were harvested from the rats,. Serum IL-10,Adiponectin and oxidative stress levels of Malondialdehyde ( MDA) and Glutathione ( GSH )were estimated.RESULTS: The results showed that the extract contain : glycosides, proteins, saponins, tannins, various phenolic compounds alkaloids , flavonoids, steroids and vitamine C . The results also showed that there were high concentrations of B, Fe , Zn respectively and low concentrations of Mn, Cu, pb,Cd respectively ,very low concentrations Ni ,Co , Se . The levels of oxidative enzymes and Inflammatory cytokines in group 3 were significantly lower than those in the group 2.Our results suggest that soursop treatment protects the rat brain against ischemia-reperfusion induced brain injuries.CONCLUSION: The present study confirm that the fruit extracts of Soursop (Annona Muricata L.) posses in vivo anti-inflammatory and antioxidant activity because of its content (glycosides , tannins , saponins ,proteins ,various phenolic compounds ,alkaloids , flavonoids, steroids and vitamine C )

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