TY - JOUR ID - TI - Coated Wire and Multiwalled Carbon Nanotube Composite Coated Wire Sensors for Determination of Chlorpromazine Hydrochloride in Pharmaceutical Preparations. AU - Riyadh M. Jihad رياض محمد جهاد AU - Ismael K. Al-Hitti اسماعيل خليل الهيتي AU - Adawiya J. Hayder عدوية جمعة حيدر PY - 2014 VL - 8 IS - 3 SP - 20 EP - 27 JO - Journal of university of Anbar for Pure science مجلة جامعة الانبار للعلوم الصرفة SN - 19918941 27066703 AB - fabrication and performance characteristics of novel potentiometric sensors for the determination of chlorpromazine hydrochloride are described. The proposed sensors include a coated copper wire sensor and a multiwalled carbon nanotube (MWCNT) composite coated copper wire sensor. The sensors are based on the chlorpromazine-phosphotungstate ion associate as electroactive material. The developed sensors exhibited near nernstian slopes of 53.69 and 57.31 mV concentration decade-1 at 25 ◦C, in the concentration range 5.0 x 10-5 – 1.0 x 10-2 mol L-1 chlorpromazine hydrochloride with limits of detection of 4.8 x 10-5 and 4.9 x 10-5 mol L-1 chlorpromazine hydrochloride for coated copper wire sensor and a (MWCNT) composite coated copper wire sensor, respectively. The proposed sensors exhibited good selectivity for chlorpromazine with respect to a large number of inorganic cations, amino acid and sugars. The developed sensor was successfully applied for the potentiometric determination of chlorpromazine hydrochloride in the pharmaceutical preparations and human urine samples.

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